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KMID : 0351219760080010083
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Korean Journal of Infectious Diseases
1976 Volume.8 No. 1 p.83 ~ p.86
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Delay of Therapeutic Effect of Antibiotics in Typhoid Fever by Prednisolone
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宋貞燮/Song, Jung-Sup
徐廷和/金在享/鄭圭源/鄭喜泳/Suh, Jeong-Hwa/Kim, Jae-Hyung/Chung, Kyu-Won/Chung, Hee-Young
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Abstract
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For the purpose of shortening of febrile period of typhoid fever, prednisolone was administered with bacteriocidal antibiotics though corticosteroid had not been used routinely for its possible side effects on typhoid fever. The authors suspected beneficial effects of corticosteroid because the action of bacteriocidal antibiotics was different from the action of bacteriostatic effects of chloramphenicol which was used in the last 30 years.
The result was quite different from expectation and the febrile period of the patients was prolonged in all of the cases as shown in figures. Corticosteroid must not be used in typhoid fever so far as it is possible because delay of antibiotic effect than other known side effect.
The possible mechanism of the longer intracellular parasitism of Salmonella typhi due to corticosteroid for the prolongation of fever was discussed.
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KEYWORD
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